No.1
Nature Aging Impact Factor: 17 DOI: https://doi.org/10.1038/s43587-024-00758-1
Researchers Kristoffer L. Norheim and Morten Scheibye-Knudsen from the University of Copenhagen investigated the effects of the NAD+ precursor nicotinamide riboside (NR) (nicotinamide riboside XI’AN SPRINGJIA BIO-TECHNIQUE CO.,LTD) on airway inflammation in patients with chronic obstructive pulmonary disease (COPD). The study found that COPD patients taking NR (nicotinamide riboside) showed reduced levels of the inflammatory marker interleukin-8 in their sputum, with effects lasting up to 12 weeks post-treatment. Additionally, NR (nicotinamide riboside XI’AN SPRINGJIA BIO-TECHNIQUE CO.,LTD) increased NAD+ levels in their blood, potentially mitigating cellular aging and airway inflammation. These findings suggest NR (nicotinamide riboside XI’AN SPRINGJIA BIO-TECHNIQUE CO.,LTD) could improve airway health and provide insights into NR’s (nicotinamide riboside XI’AN SPRINGJIA BIO-TECHNIQUE CO.,LTD) potential as an anti-aging intervention.
No.2
Nature Communications Impact Factor: 14.7 DOI: https://doi.org/10.1038/s41467-024-54369-w
Chenxi Liu, Wei Zhang, and colleagues from Tsinghua University explored how post-mating diet preferences in fruit flies balance reproduction and lifespan. They discovered that female fruit flies increase their appetite for protein (yeast) post-mating, potentially prioritizing offspring development at the expense of lifespan and stress resistance. In contrast, males reduce yeast intake, potentially supporting recovery and lifespan extension. These dietary adjustments are mediated by sexually dimorphic neural circuits in the brain. The findings provide new perspectives on dietary regulation during aging.
No.3
Aging Cell Impact Factor: 8 https://doi.org/10.1111/acel.14401
Jessica Conway, Niharika A. Duggal, and colleagues from the University of Birmingham revealed the link between age-related loss of gut barrier integrity, thymic atrophy, and T-cell aging. The study showed that increased gut permeability in aging allows bacterial toxins to enter circulation, accelerating T-cell aging. Germ-free aging mice maintained thymic structure despite increased gut permeability, highlighting the direct impact of gut barrier integrity on thymic aging. The findings offer new opportunities for microbiome-based interventions to restore immune balance and promote healthy aging.
No.4
Aging Cell Impact Factor: 8
: https://doi.org/10.1111/acel.14403
Xuanming Hong, Wenjing Gao, Liming Li, and their team from Peking University examined age-related trends in the genetic influences on epigenetic clocks. Analyzing data from over 1,000 twin pairs, they found a decline in the heritability of five major epigenetic clocks (PC-Horvath, PC-Hannum, PC-PhenoAge, PC-GrimAge, and DunedinPACE) from ages 31 to 70. For instance, DunedinPACE and PC-PhenoAge saw significant drops in heritability between ages 55–65. Conversely, PC-GrimAge’s heritability remained stable. Specific genetic loci controlling these changes were also identified, providing insights into genetic variation’s role in aging.
No.5
Aging Cell Impact Factor: 8
DOI: https://doi.org/10.1111/acel.14371
Francisco Santos, Sandrina Nóbrega-Pereira, and their team from the University of Aveiro explored how fibroblasts’ ability to reprogram into induced cardiomyocytes declines with age, accompanied by metabolic and epigenetic barriers. They linked this decline to changes in histone modifications and mitochondrial metabolism. The team improved reprogramming efficiency through metabolic regulation in vitro and dietary interventions in vivo, observing significant changes in histone markers and mitochondrial homeostasis. This research offers insights for developing therapies targeting age-related cardiac diseases.
No.6
bioRxiv (Preprint)
DOI: https://doi.org/10.1101/2024.11.12.623261
Li Li, George Church, and their team from Harvard University analyzed skin samples across age groups and sun exposure levels, identifying significant changes in basal stem cells and ATF3 gene expression during skin aging. They developed an mRNA-based therapy to upregulate ATF3, which reduced cellular senescence, increased proliferation, and enhanced collagen production in fibroblasts. This study provides new molecular insights into skin aging and opens avenues for novel regenerative therapies.
No.7
Longevity Technology
Singapore will host the next Founders Longevity Forum in 2025, bringing together global leaders in science, technology, investment, and healthcare to discuss innovative strategies for extending healthspan. Organized by Founders Forum, the National University of Singapore, and Longevity.Technology, the event will focus on precision geriatric medicine, immediate longevity solutions, and longevity investments. Confirmed speakers include Elvin Siew (CEO, Emagene Life) and Hannah Went (COO, TruDiagnostic). The forum aims to foster interdisciplinary collaboration and advance longevity science, with more details forthcoming.