Scholars from Wuhan University of Science and Technology, including Ao-jia Zhou, Shuang Rong, and Ting Wang, investigated the effects of long-term supplementation of Nicotinamide Mononucleotide (NMN β-Nicotinamide Mononucleotide, CAS No. 1094-61-7) on the physiological decline induced by a high-fat diet in aging mice. In the study, 14-month-old mice were fed a high-fat diet and supplemented with 400 mg/kg NMN in their drinking water for 7 months. The results showed that NMN supplementation increased the NAD+ levels in the mice and alleviated the physiological decline associated with aging and diet. NMN inhibited obesity caused by the high-fat diet, improved physical activity, enhanced glucose and lipid metabolism, improved skeletal muscle function, reduced kidney damage, and lowered levels of aging and inflammation markers. Furthermore, the study highlighted the bidirectional relationship between NAD+ and autophagy, detecting changes in autophagy levels across various tissues and organs, suggesting that NMN may protect by inhibiting excessive autophagy induced by a high-fat diet. The findings emphasize that NMN therapy can alleviate metabolic disorders and physiological decline in aging mice caused by a high-fat diet, providing new evidence for the development of NMN as an effective anti-aging compound and helping to prevent physiological decline due to aging and diet.
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